Following the resignation of Majority Leader Osei Kyei-Mensah-Bonsu, the New Patriotic Party (NPP) was expected to elect a new leader to take over.

Before Kyei-Mensah-Bonsu's resignation, internal dynamics within the party showed both opposition to and support for his leadership.

While some members believed it was time for a change, others, led by First Deputy Speaker Joe Osei Owusu, argued against forcing Kyei-Mensah-Bonsu out.

Kyei-Mensah-Bonsu's resignation, after a meeting at the presidency on February 21, paved the way for the Majority Caucus to have a new leader.

Just 24 hours after his departure, Alexander Kwamina Afenyo-Markin, the Deputy Majority Leader, was formally announced as the new Majority Leader, with Asokwa MP Patricia Appiagyei stepping up as the new Deputy Majority Leader.

Afenyo-Markin, born on May 27, 1978, currently serves as the Member of Parliament for the Effutu constituency in the Central Region. He is also a member of the Committee on Defense and Interior in Parliament.

Prior to his elevation to Majority Leader, Afenyo-Markin served as the Deputy Majority Leader in the 8th Parliament.

His educational background includes studying law at the University of Buckingham (LLB/MGT, 2003–2006) and earning a Barrister at Law certification from the Ghana School of Law (2007–2009). He further pursued an M.A. in international politics and security studies at the University of Bradford (2009–2010).

Before entering politics, Afenyo-Markin worked as a principal postal officer at the Ghana Post Company Limited from 1999 to 2003. He also served as the Director at Excel Courier Ghana Limited from 2004 to 2011 and as an Associate at Dehenya Chambers from 2010 to 2016.

Afenyo-Markin won his seat on the NPP ticket against the National Democratic Congress (NDC) parliamentary candidate, Mike Allen Hammah, in 2012. He assumed the chairmanship of the Ghana Water Company Ltd. (GWCL) in 2017, although allegations of involvement in the near collapse of GWCL and financial improprieties led to a defamation lawsuit.

In 2021, he participated in the Extraordinary Session 2021 of the Parliament of the ECOWAS in Freetown, Sierra Leone, along with other Ghanaian legislators.

Afenyo-Markin is recognized for championing "The Effutu Dream," an initiative launched in February 2020 to promote Effutuman culture, foster a sense of belonging among youth, and attract tourists and investors to the constituency.