When one of their great players gets injured, fantasy football managers around the world cringe because a trip to the hospital is never good news.
Here is all the Premier League injuries and expected return dates throughout the season.
Takehiro Tomiyasu (knee): Japanese full-back will miss the rest of the season after needing surgery.
Eddie Nketiah (ankle): Still a few weeks away from making a return.
Thomas Partey (other): Small issue kept the midfielder out of action for Ghana during the international break.
Kieran Tierney (knock): Substituted after receiving a tough tackle in Scotland’s win over Spain.
Mohamed Elneny (knee): Egyptian midfielder has undergone surgery and will be out for an extended period.
William Saliba (back): French defender was substituted in the Europa League exit to Sporting and not fit to face Leeds.
Matty Cash (calf): Likely to miss a couple of weeks after picking up a problem on international duty with Poland.
Philippe Coutinho (thigh): Not fit to face Chelsea.
Leander Dendoncker (hand): Ready to play for Unai Emery.
Boubacar Kamara (lower leg): Likely to be included in the squad for the clash at Stamford Bridge.
Jed Steer (Achilles): Goalkeeper is a long-term absentee.
Keane Lewis-Potter (knee): Could miss the run-in.
Kristoffer Ajer (calf): Hoping to be fit before the end of the season.
Shandon Baptiste (suspended): Sent off for two bookable offences against Leicester.
Mads Roerslev (hamstring): Right-back is available to face Brighton.
Vitaly Janelt (knee): Absent this weekend and being assessed.
Adam Lallana (hamstring): Could feature before the end of the season.
Jakub Moder (knee): Stepping up recovery after rupturing his ACL.
Tariq Lamptey (knee): Could return against Brentford but more likely at Bournemouth on Tuesday.
Levi Colwill (muscular): Chelsea loanee is nearing a return to action.
Jeremy Sarmiento (metatarsal): Will miss an extended period after picking up an injury while on international duty with Ecuador.
Illia Zabarnyi (ankle): January signing back available to boss Gary O’Neil.
Marcus Tavernier (hamstring): Fully fit and able to face Fulham.
Junior Stanislas (unknown): Winger hoping to return soon.
Armando Broja (knee): Torn ligaments will keep young striker out for rest of the season.
Thiago Silva (knee): Ligament damage will keep the Brazilian defender on the sidelines.
Kai Havertz (fever): Has recovered from illness.
Cesar Azpilicueta (concussion): Remains out of action as he continues protocol.
Mason Mount (abdomen): Trained and is available.
Edouard Mendy (hand): Goalkeeper needed surgery to repair a fractured finger and is back in training.
Raheem Sterling (hamstring): Hoping to return to action against Liverpool on Tuesday.
Pierre-Emerick Aubameyang (back): Absent since the defeat at Tottenham.
Wesley Fofana (hamstring): Will miss the Aston Villa clash.
Reece James (illness): Should be available to boss Graham Potter.
Christian Pulisic (cold): American returned from international duty with a bug.
Chris Richards (other): Roy Hodgson hoping the defender will be back next week.
Nathan Ferguson (unknown): Another who could return to the fold following the Leicester game.
Sam Johnstone (calf): Goalkeeper is back fit.
James McArthur (illness): Scottish midfielder has not played since the start of the month.
Vicente Guaita (hamstring): Should return between the sticks against the Foxes.
Joachim Andersen (calf): Danish centre-back missed the defeat at Arsenal before the international break.
Andros Townsend (knee): Has suffered a setback which will keep him out until May.
Dominic Calvert-Lewin (hamstring): Progressing well but has not returned to full training.
Neeskens Kebano (Achilles): Out for the rest of the campaign.
Aleksandar Mitrovic (suspended): Sent off in FA Cup defeat at Manchester United.
Willian (suspended): Also given his marching orders at Old Trafford.
Shane Duffy (calf): Irish defender has been absent since the start of February.
Layvin Kurzawa (knee): Not available following ligament injury.
Max Wober (hamstring): Picked up issue on international duty with Austria.
Stuart Dallas (leg): Had a second operation following a fractured femur.
Adam Forshaw (hip): Seeking expert advice to solve issue.
Tyler Adams (hamstring): American has undergone surgery but is now doubtful to return before the end of the season.
Wilfried Gnonto (ankle): Limped off during Italy’s win over Malta.
James Justin (Achilles): Ruptured his Achilles against Newport in the Carabao Cup and is out for the season.
Youri Tielemans (ankle): Belgian ace has suffered a setback in his recovery.
Harry Souttar (ankle): Aussie defender should be fine despite returning early from international duty.
Dennis Praet (dead leg): A doubt for the trip to Crystal Palace.
Victor Kristiansen (ankle): Trained this week and in contention to face Palace.
Jonny Evans (hamstring): Back in training and recovering well.
Ryan Bertrand (knee): Long-term absentee is training but needs to build his fitness before a first-team return.
Jannik Vestergaard (other): Training away from the first team due to an internal disciplinary matter.
Calvin Ramsay (knee): Young Scottish defender out until next season.
Stefan Bajcetic (thigh): Also ruled out until the summer.
Thiago Alcantara (hip): Spaniard expected to return to training next week.
Luis Diaz (knee): Colombian is in training but will not play against Manchester City.
Joe Gomez (knock): Back fit and likely to make the squad that travels to the Etihad.
Darwin Nunez (foot): Picked up a cut against Real Madrid but in contention to take on Pep Guardiola’s title chasers.
Kostas Tsimikas (unknown): Subbed off after 24 minutes of Greece’s draw with Lithuania.
Naby Keita (other): Returned from international duty with a muscle injury.
Phil Foden (appendix): Out for at least two weeks following surgery.
Erling Haaland (groin): In recovery and hoping to be fit to face Liverpool.
Donny van de Beek (knee): Dutchman is out for the rest of the season.
Casemiro (suspended): Serving a four-match ban after receiving his second red card of the season against Southampton.
Christian Eriksen (ankle): Was on the wrong end of an Andy Carroll challenge against Reading and could be out until May.
Marcel Sabitzer (knock): Doubtful after sustaining a problem for Austria against Azerbaijan.
Anthony Martial (hip): Set to be named in Erik ten Hag’s squad for the first time since early February.
Raphael Varane (other): French defender a doubt to feature at Newcastle.
Marcus Rashford (toe): Ten Hag hopeful the homegrown hero will be available for the game at St James’ Park.
Tom Heaton (ankle): Keeper should be available by the end of April.
Alejandro Garnacho (ankle): Suffered ligament damage in the draw with Southampton.
Miguel Almiron (thigh): Fan favourite will spend four weeks on the sidelines.
Anthony Gordon (ankle): Young winger has returned to training.
Allan Saint-Maximin (hamstring): Available despite being subbed off at Nottingham Forest.
Nick Pope (thigh): England stopper withdrew from Three Lions squad but Eddie Howe hoping to have him back between the posts.
Sven Botman (food poisoning): Available despite issues during the international break.
Ryan Fraser (other): Training with the Under-21s for the time being.
Emil Krafth (knee): Will miss a lengthy stretch of time with an ACL injury.
Chris Wood (thigh): Ruled out for the rest of the season.
Willy Boly (hamstring): Defender may not play again this season.
Dean Henderson (thigh): Continuing his recovery.
Serge Aurier (knock): Picked up an issue during the international break.
Andre Ayew (knock): Another who is now a doubt after sustaining a new injury.
Wayne Hennessey (knee): Welsh keeper sat out international duty as he remains sidelined.